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Journal Club Global: Moving leiomyoma research from bench to bedside


Uterine leiomyomata are benign tumors that develop during the reproductive years with a 70-80% prevalence by menopause. While hysterectomy is definitive treatment, many women desire to preserve their potential fertility. Myomectomy is a useful surgical procedure for leiomyomas inside the uterine cavity. Medical therapies are available but are primarily temporary in effect and primarily act through decreasing estradiol action, leading to additional risks related to hypoestrogenism. Leiomyomas may return to pre-treatment size after medication discontinuation and most of these medical therapies are incompatible with patients attempting to achieve pregnancy. There is a need for non-hormonal, easily accessible, and affordable treatments for leiomyoma. This Journal Club Global discusses the article “Curcumin inhibits human leiomyoma xenograft growth and induces dissolution of extracellular matrix” recently published in F&S Science. Topics include: • What is curcumin? • How does curcumin mechanistically impact leiomyomas? • Discuss the pros and cons of 2-D, 3-D, and xenograft models in the laboratory study of human disease? • What is the data on other nutritional supplements for leiomyoma prevention or reduction? • What is the pathophysiology of leiomyoma growth and infertility?

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Journal Club Global from MEFS 2024

Explore BMI's impact on IVF outcomes in a global fertility discussion, analyzing studies, obesity trends, and regional variations in reproductive health care.

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Journal Club Global from ASRM 2024: Obesity and Reproduction

Join experts from Fertility and Sterility Journal Club as they explore the impact of obesity on reproduction, weight loss interventions, and emerging treatments in fertility.

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Journal Club Global en Español: De la Reunión de la SAMER 2024

 Onsite de la Reunión de la Sociedad Argentina de Medicina Reproductiva (SAMER) de Córdoba, Argentina

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Journal Club Global from ANZSREI 2024: Debate Unexplained infertility; Straight to IVF?

ANZSREI 2024 debate: Should unexplained infertility go straight to IVF? Experts discuss pros, cons, and alternative treatments. No clear consensus reached.

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Journal Club Global en Espanol: Actualizacion sobre el síndrome de ovario poliquístico

Fertility & Sterility se enorgullece de traer un Journal Club Global en Español en vivo desde Cancún, Mexico

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Journal Club Global: Oral Progestin For Ovulation Suppression During IVF

Live broadcast from the 2024 Midwest Reproductive Symposium
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Journal Club Global: Recent clinical trials in Fertility and Sterility from the Asia Pacific region

Join ASPIRE 2024 for a Journal Club Global on PGT-A and IVF. Learn from top experts discussing recent clinical trial data and pregnancy outcomes

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Journal Club Global en Español: Avances recientes en el tratamiento del síndrome de ovario poliquístico e Infertilidad

Un panel de expertos discutirá dos artículos recientes de Fertility and Sterility que estudian la infertilidad y el síndrome de ovario poliquístico.

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Journal Club Global: Cost effectiveness analyses of PGT-A

Infertility treatments can be financially burdensome, often without insurance coverage, making understanding the cost effectiveness of PGT-A crucial.

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Journal Club Global: The future of REI Fellowship training: debating opportunities and threats

This exciting collaboration discusses the controversy and future directions for the field of Reproductive Endocrinology and Infertility medicine.

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Journal Club Global: Infertility and Subclinical Hypothyroidism

The impact of treating SCH on fertility, obstetric outcomes, and offspring neurocognitive development is debated in the literature.

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Journal Club Global: Actualidad En Tratamientos De Fertilidad Para Pacientes Con Endometriosis

Live in Spanish from the 2024 Peruvian Fertility Society Meeting - Lima, Peru

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Journal Club Global - Recurrent implantation failure: Reality or statistical mirage?

This exciting new collaboration brings authors and experts to discuss the controversy and future directions for recurrent implantation failure.

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Journal Club Global - Evidence based guidelines for PCOS

This virtual event discusses the international guidelines for the assessment and management of PCOS, conducted by the International PCOS Network.

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Journal Club Global - Recurrent implantation failure: Reality or statistical mirage?

This exciting new collaboration brings authors and experts to discuss the controversy and future directions for recurrent implantation failure.

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Journal Club Global - The Association of Ovarian Reserve and Embryo Aneuploidy

Recent research suggests that the Antimullerian hormone (AMH) may not reliably predict embryo health in both infertility and non-infertility cases.

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Journal Club Global - Actualización en la suplementación con progesterona en fase lútea para transferencias de embriones congelados

Efectividad del rescate de progesterona en mujeres que presentan niveles bajos de progesterona circulante alrededor del día de la transferencia de embriones

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Journal Club Global - Revisiting the STAR trial: The Fellows debate PGT-A

We are excited to host a debate covering the pros and cons of PGT-A and how new technologies should be validated before clinical implementation.

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Journal Club Global: Absolute uterine infertility a Cornelian dilemma: uterine transplantation or surrogacy?

Absolute uterine infertility presents as a Cornelian dilemma for patients and providers.

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Journal Club Global: Transferencia de embriones frescos versus congelados: ¿Cuál es la mejor opción

Los resultados de nuevas técnicas de investigación clínica que utilizan información de bancos nacionales de vigilancia médica.  

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Journal Club Global: IVM in Clinical Practice: An Idea Whose Time Has Come?

In vitro maturation (IVM) has the potential to make IVF cheaper, safer, and more widely accessible to patients with infertility.

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Journal Club Global - What is the optimal number of oocytes to reach a live-birth following IVF?

The optimal number of oocytes necessary to expect a live birth following in vitro fertilization remains unclear.

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Journal Club Global: Surgical management of endometriosis in women diagnosed with infertility (Spanish language)

Fertility and Sterility is excited to partner with our global professional colleagues to begin broadcasting regular Journal Club Global events in Spanish.

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Journal Club Global: Natural versus Programmed FET Cycles

A significant portion of IVF cycles now utilize frozen embryo transfer.

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Journal Club Global: Moving leiomyoma research from bench to bedside

Uterine leiomyomata are benign tumors that develop during the reproductive years with a 70-80% prevalence by menopause.

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Journal Club Global: Does diminished ovarian reserve impact embryo aneuploidy or live birth rates?

Do patients with diminished ovarian reserve (DOR) have poor outcomes because of lower ovarian response, or because of additional factors that affect the egg quality.

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Journal Club Global: Is PGT-P cutting edge or should we cut it out?

PGT for polygenic risk scoring (PGT-P) is a novel screening strategy of embryos for polygenic conditions and traits.

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Journal Club Global: Should everyone freeze oocytes by age 33?

Oocyte cryopreservation is one of the fastest growing areas of reproductive medicine.

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Journal Club Global: Management of poor ovarian response

A poor ovarian response to what should otherwise be a successful stimulation cycle presents a clinical conundrum for clinicians.

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Journal Club Global: Non-invasive Diagnosis of Endometriosis

One of the most exciting developments in the field of endometriosis is the push towards earlier and less invasive approaches to diagnosis.

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Journal Club Global: Prognosis in unexplained RPL

Recurrent pregnancy loss is one of the bigger challenges in the field of reproductive medicine.

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Journal Club Global: Evidence for Immunologic Therapies in Women Undergoing ART

Reproductive immunology is perhaps one of the most controversial and promising fields within ART.

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Journal Club Global Live from PCRS - Non-Invasive Embryo Selection Techniques

The next great frontier in reproductive medicine is how to non-invasively select an embryo with the highest reproductive potential for transfer.

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Journal Club Global Live from PCRS - ICSI for Non-Male Factor Infertility

While intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male factor infertility, a significant controversy still remains regarding its ubiquitous use in all IVF cycles.

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Journal Club Global - To Operate Or Not To Operate: Debating Intramural Fibroids And Fertility

The event will debate the upcoming F&S Fertile Battle “Intramural myomas more than 3 to 4 cm should be surgically removed before IVF”.

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Journal Club Global - PGT-A - Can non-invasive approaches based on spent medium analysis

PGT-A by trophectoderm biopsy aims to select available euploid embryos for transfer.

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Journal Club Global - Obesity & Reproduction: An Update on Management and Counseling

Obesity can negatively impact reproduction in various ways, including ovulatory and menstrual function, natural fertility and fecundity rates, infertility treatment success rates, infertility treatment safety, and obstetric outcomes

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Journal Club Global - Does the Endometrium Play a Major Role in Endometriosis-Associated Infertility

This will be a virtual event in the style of the "Fertile Battle" debate that took place at the 2019 SREI Fellows Symposium

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Journal Club Global - Best Practices of High Performing ART Clinics

This Fertility and Sterility Journal Club Global discusses February’s seminal article, “Common practices among consistently high-performing in vitro fertilization programs in the United States: a 10 year update.”

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Journal Club Global - Should Fellows Perform Live Embryo Transfers in Fellowship?

Few things are more taboo in reproductive medicine fellowship training than allowing fellows to perform live embryo transfers.

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Journal Club Global - Fertilization rate as a novel indicator in ART results

This Journal Club Global discusses a provocative article recently published in Fertility and Sterility, discussing the results of a multicenter retrospective cohort study with the objective to appraise the fertilization rate as a predictive factor for cumulative live birth rate (CLBR).

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Journal Club Global Live from ASRM - Optimal Management of the Frozen Embryo Transfer Cycle: Insights From Recent Literature

Three recent papers published in the Fertility and Sterility family of journals, all explore different aspects of optimizing frozen embryo transfer cycles.

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Journal Club Global - Are We Approaching Automation in ART?

Some ART diagnostic devices are already available and offer objective tools of evaluation.

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Journal Club Global Live from India - Adjuvants in IVF and IVF Add-Ons for the Endometrium

Many adjuvants have been utilized by IVF centers to improve their success rates.

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Journal Club Global - Accuracy of Preimplantation Genetic Testing for Aneuploidies

One of the highest aspirations in reproductive medicine is to develop a technology allowing for ID of embryos that have true reproductive potential.

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Club Global Académico - ¿Cual debe de ser la primera línea de tratamiento en parejas con infertilidad inexplicable?

Nuestro debate se enfocará en el manejo óptimo de la infertilidad inexplicable, y como el problema debe de ser abordado en Latinoamérica basado en la literatura global reciente.

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Journal Club Global - Recurrent Implantation Failures in ART: Myth or Reality?

Classically, implantation failures in ART were believed to result from alterations in embryo or endometrium quality.

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Fertility and Sterility

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F&S Reports

F&S Reports is an open-access journal that publishes peer-reviewed original scientific articles in clinical and translational research that have strong potential to transform clinical practice.

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F&S Reviews

F&S Reviews publishes both systematic and comprehensive, authoritative review articles spanning reproductive medicine or science.

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F&S Science

F&S Science publishes peer-reviewed original scientific articles in basic, laboratory, and translational research that has strong potential to transform clinical practice.

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Fertility and Sterility

Fertility and Sterility® is an international journal for health professionals who treat and investigate problems of infertility and human reproductive disorders.

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Journal Club Global

Fertility and Sterility Journal Club Global is an interactive online discussion of a hot topic or seminal article from Fertility and Sterility. 

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