ICSI and Embryo Biopsy
How to bill for ICSI or embryo biopsies that occur in different days? So if 8 eggs were ICSI fertilized on one day but then the next day 4 more were ICSI’d would we then bill the 89281 code for the second day? Same with PGTA?
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Coding Q&A
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Billing for Ultrasounds and Labs
When billing for ultrasounds and labs, is it necessary
Use of Code 99211 for a Monitoring Appointment
Is it appropriate to use code 99211 if a patient is scheduled for a monitoring visit
Appropriate Use of Modifier -25
Is Modifier -25 appropriate in the monitoring cycle when an ultrasoundCoding Corner
Coding Corner is segmented into the following sections. Click an image below to view questions and answers in that section.
More Resources
ASRM Practice Documents
These guidelines have been developed by the ASRM Practice Committee to assist physicians with clinical decisions regarding the care of their patients.
ASRM Academy on the Go
ASRM MAC Tool 2021
The ASRM Müllerian Anomaly Classification 2021 (MAC2021) includes cervical and vaginal anomalies and standardize terminology within an interactive tool format.
Practice Guidance
Coding Corner Q & A
The Coding Corner Q & A is a list of previously submitted and answered questions from ASRM members about coding. Answers are available to ASRM Members only.
Practice Guidance
EMR Shared Phrases/Template Library
This resource includes phrases shared by ASRM physician members to provide a template for individuals to create their own EMR phrases.
ASRM Ethics Opinions
Ethics Committee Reports are drafted by the members of the ASRM Ethics Committee on the tough ethical dilemmas of reproductive medicine.
Practice Guidance
COVID-19 Resources
A compendium of ASRM resources concerning the Novel Corona virus (SARS-COV-2) and COVID-19.
Patient Resources
ReproductiveFacts.org provides a wide range of information related to reproductive health and infertility through patient education fact sheets, infographics, videos, and other resources.
Topic Resources
View more on the topic of intracytoplasmic sperm injection (ICSI)
Codes for Embryo Biopsy
When doing a preimplantation genetic test (PGT) biopsy, can you bill for each day a biopsy is performed or can you only bill once for the cycle? View the Answer
Oocyte Denudation
Is there is a separate code for denudation of oocytes? View the Answer
Denudation of Oocytes
Is there is a separate code for denudation of oocytes? And if denuding oocytes is bundled into another code for either IVF or ICSI, please explain. View the Answer
Egg Culture and Fertilization: Same Gender
A same-sex male couple requested half their donor eggs be fertilized with sperm from male #1 and the other half fertilized from male #2. View the Answer
Intracytoplasmic sperm injection (ICSI) for non–male factor indications: a committee opinion (2020)
Intracytoplasmic sperm injection is frequently used in combination with assisted reproductive technologies. View the Committee DocumentTopic Resources
View more on the topic of embryo
Journal Club Global en Español: AMMR 2025
Experts discuss chaotic embryo classification, PGT-A rebiopsy outcomes, embryo quality, biopsy techniques, and transfer protocols for mosaic embryos. View the Video
Transfer of embryos affected by monogenic conditions: an Ethics Committee Opinion (2025)
Patient requests to transfer embryos with serious monogenic disorders detected in preimplantation testing are rare; this opinion discusses physician responses. View the Committee Opinion
How to bill for an FET
Is there a new update to the 89272 code that allows its use without View the Answer
Codes for Embryo Biopsy
When doing a preimplantation genetic test (PGT) biopsy, can you bill for each day a biopsy is performed or can you only bill once for the cycle? View the Answer
Billing for assisted hatching at biopsy and transfer
We would also like to know if you can bill assisted hatching with biopsy and then assisted hatching again during the transfer cycle. View the Answer
Shipping of frozen embryos
I have some infertility coverage, under which my insurance said they will cover frozen embryo shipping/transport from one facility to another. View the Answer
Clinical management of mosaic results from preimplantation genetic testing for aneuploidy of blastocysts: a committee opinion (2023)
This document incorporates studies about mosaic embryo transfer and provides evidence-based considerations for embryos with mosaic results on PGT-A. View the Committee Opinion
How to EDGE
Explore the ASRM EDGE tool for embryo grading. Learn grading steps, view dashboards, and assign blastocyst grades using the SART and Gardner scales in ASRM Academy. View the ASRMed Talk Video
Journal Club Global: Transferencia de embriones frescos versus congelados: ¿Cuál es la mejor opción
Los resultados de nuevas técnicas de investigación clínica que utilizan información de bancos nacionales de vigilancia médica. View the Video
Defining embryo donation: an Ethics Committee opinion (2023)
The ethical appropriateness of patients donating embryos to other patients for family building, or for research, is well established.
View the Committee Opinion
Does the number of eggs being frozen matter?
There is currently only one CPT code for the cryopreservation of mature oocytes and embryos. View the Answer
Reproductive Tissue Storage
What are the CPT codes for the Storage of Reproductive Cells/Tissues? View the Answer
ICSI and Embryo Biopsy
How to bill for ICSI or embryo biopsies that occur in different days? View the Answer
Lab RVUs
Is there a list of RVUs for embryology and andrology laboratory procedures, and if so, where can it be found? View the Answer
Embryo Biopsy
Have any new codes been introduced for the lab portion of PGT? View the Answer
Embryo Biopsy Embryologist Travel Costs
Can we bill insurance for the biopsy procedure? Can we bill for travel expenses? View the Answer
Embryo Biopsy PGS Testing
What codes are appropriate for PGS testing? View the Answer
Embryo Co-culture
Can codes 89250 and 89251 be billed on different days of the same cycle? View the Answer
Embryo Culture Denied As Experimental
We have received denials from insurance payers when billing CPT code 89251. View the Answer
Embryo Culture Less Than And More Than Four Days
When coding 89250 culture of oocytes/embryo <4 days, should that code be submitted to the insurance company for each of the days? View the Answer
Embryo Freezing/Thawing
Our question refers to the CPT code 89258 “Cryopreservation; Embryo(s)” and 89352 “Thawing of Cryopreserved; Embryo”. View the Answer
Embryo Storage Fees For Multiple Cycles
We bill embryo storage 89342 for a year's storage. View the Answer
Embryo Thawing/Warming
Is it allowable to bill 89250 for the culture of embryos after thaw for a frozen embryo transfer (FET) cycle? View the Answer
Gamete Thawing/Warming
Can patients be charged for each vial/straw of reproductive gametes or tissues thawed? View the Answer
D&C Under Ultrasound Guidance
What are the CPT codes and ICD-10 codes for coding a surgical case for a patient with history of Stage B adenocarcinoma of the cervix ... View the Answer
Assisted Hatching Billed With Embryo Biopsy
Do you know if both assisted hatching (89253) and embryo biopsy for PGS/PGD/CCS (89290/89291) can be billed during the same cycle? View the Answer
Assisted Zona Hatching
Can assisted hatching and embryo biopsy for PGT-A; PGT-M or PGT-SR be billed during the same cycle? View the Answer
Billing For Cryopreservation Of Embryos Under The Male Partner
Can 89258 be billed under the male partner of a female patient? View the Answer
Embryo Transfer
A summary of Embryo Transfer codes collected by the ASRM Coding Committee View the Coding Summary
Journal Club Global: Is PGT-P cutting edge or should we cut it out?
PGT for polygenic risk scoring (PGT-P) is a novel screening strategy of embryos for polygenic conditions and traits. View the Video
Disposition of unclaimed embryos: an Ethics Committee opinion (2021)
Programs should create and enforce written policies addressing the designation, retention, and disposal of unclaimed embryos. View the Committee Opinion
A review of best practices of rapid-cooling vitrification for oocytes and embryos: a committee opinion (2021)
The focus of this paper is to review best practices for rapid-cooling cryopreservation of oocytes and embryos. View the Committee Opinion
Ethics in embryo research: a position statement by the ASRM Ethics in Embryo Research Task Force and the ASRM Ethics Committee (2020)
Scientific research using human embryos advances human health and offspring well-being and provides vital insights into the mechanisms for reproduction. View the Committee Opinion
Guidance for Providers Caring for Women and Men Of Reproductive Age with Possible Zika Virus Exposure (Updated 2019)
This ASRM guidance specifically addresses Zika virus infection issues and concerns of individuals undergoing assisted reproductive technologies (ART). View the Guideline
Blastocyst culture and transfer in clinically assisted reproduction: a committee opinion (2018)
The purposes of this document is to review the literature regarding the clinical application of blastocyst transfer. View the Committee Opinion
Posthumous retrieval and use of gametes or embryos: an Ethics Committee opinion (2018)
Posthumous gamete retrieval or use is ethically justifiable if written documentation from the deceased authorizing the procedure is available. View the Committee Opinion
Recommended practices for the management of embryology, andrology, and endocrinology laboratories: a committee opinion (2014)
A general overview for good management practices within the endocrinology, andrology, and embryology laboratories in the United States. View the Recommendation
ASRM EDGE Tool
Get the EDGE on your fellow Embryologists! As the grading of embryos varies within IVF laboratories and between laboratories, EDGE allows you to compare yourself against embryologists in the US and around the world. Learn more about the EDGE ToolTopic Resources
View more on the topic of genetic screening/testing
Fertility and Sterility On Air: Live from the ESHRE 41st Annual Meeting (Part 2)
Live from ESHRE Paris 2025: Fertility & Sterility On Air features latest IVF, AI, embryo genetics & implantation research with top global experts. Listen to the Episode
Fertility and Sterility On Air: Live from the ESHRE 41st Annual Meeting (Part 1)
Live from ESHRE 2025 in Paris, F&S On Air explores frozen embryo transfer protocols, ovarian aging, and the reproductive microbiome. Listen to the Episode
Journal Club Global LIVE at ANZSREI 2025
ANZSREI panel reviews a PGT-A study on male age and sperm factors in blastulation and euploidy, finding female age dominates and calling for better research. View the Video
Fertility and Sterility On Air - TOC: September 2025
Fertility & Sterility On Air: Sept 2025—podcast on infertility advances, AZFC outcomes, BMI & IVF safety, endometrium, chorionic bump, AMH-PCOS, GLP-1. Listen to the Episode
Journal Club Global en Español: AMMR 2025
Experts discuss chaotic embryo classification, PGT-A rebiopsy outcomes, embryo quality, biopsy techniques, and transfer protocols for mosaic embryos. View the Video
Fertility and Sterility On Air - TOC: August 2025
Fertility and Sterility marks 75 years with debates on PGT-A, Dobbs impacts, ART risks, contraception trends, and advances shaping reproductive medicine. Listen to the Episode
Journal Club Global LIVE at MRSi 2025: Sibling Oocyte Studies in ART
Experts discuss sibling oocyte trials, PIEZO-ICSI, and microfluidics in ART, evaluating outcomes, design limits, lab impact, and clinical implications. View the Video
Unlocking the Future of IVF: Navigating the Complex World of IVF Genomics
Explore the rise of IVF genomics, from PGT-A to WGS and polygenic risk scores, with insights on ethics, costs, and future implications for embryo screening. Read the Blog post
Fertility and Sterility On Air - Live from the PCRS 2025 Annual Meeting
Explore cutting-edge fertility research from PCRS 2025—PGT-A, embryo screening, cost-effective protocols, and gamete storage breakthroughs. Listen to the Episode
ASRM Today: Genetics - Season Three Reflection
Explore genetics in reproduction, IVF, aging, and ethics with ASRM Today. Discover how DNA research is shaping medicine, identity, and the future. Listen to the Episode
ASRM Today: Genetics Bonus Episode - Inclusive Family History Project
Explore how inclusive family histories improve healthcare for donor-conceived and adopted individuals with new EHR standards and provider education tools. Listen to the Episode
Fertility and Sterility On Air - TOC: June 2025
Stay updated on global reproductive medicine with Fertility & Sterility On Air—insights, debates, and journal highlights hosted by leading experts. Listen to the Episode
ASRM Today: Genetics - Episode Nine
Explore ethics, identity, and humanity in a dystopian love story as ASRM Today discusses Never Let Me Go through the lens of genetics and reproduction. Listen to the Episode
ASRM Today: Genetics - Episode Eight
Explore ethical considerations in embryo transfer, PGTM, and genetic testing with Dr. Sigal Klipstein on ASRM Today’s genetics-focused podcast episode. Listen to the Episode
ASRM Today: Genetics - Episode Seven
Dr. Elizabeth Ginsburg discusses PGTA, its benefits, limitations, and proper use in IVF based on age, ovarian reserve, and embryo quality on ASRM Today. Listen to the Episode
ASRM Today: Genetics - Episode Six
Explore how genetics may unlock the secrets to longevity, reverse aging, and extend life through telomeres, gene therapy, and cellular reprogramming. Listen to the Episode
Fertility and Sterility On Air - TOC: May 2025
Explore new fertility research on IVF triggers, thyroid autoimmunity, prednisone use, and genetic impacts in this expert-led review of May 2025’s F&S journal. Listen to the Episode
ASRM Today: Genetics - Episode Five
Explore how personalized medicine is transforming reproductive healthcare, from IVF optimization to ethical issues in genetic testing and AI-driven care. Listen to the Episode
Fertility and Sterility On Air - Best of ASRM and ESHRE 2025
Experts explore recurrent pregnancy loss, embryo testing, IVF mental health, and stem cell banking at ASRM–ESHRE 2025. Insights from leading fertility voices. Listen to the Episode
ASRM Today: Genetics - Episode Four
Explore how genetics shapes agriculture and reproductive medicine, from GMOs to CRISPR and lab-grown meat, in this ASRM Today podcast episode. Listen to the Episode
Transfer of embryos affected by monogenic conditions: an Ethics Committee Opinion (2025)
Patient requests to transfer embryos with serious monogenic disorders detected in preimplantation testing are rare; this opinion discusses physician responses. View the Committee Opinion
Journal Club Global: Embriões mosaicos ao Teste Genético Pré-Implantacional para Aneuploidia (PGT-A): o que fazer?
Discutiremos embriões mosaicos ao teste genético pré-implantacional para aneuploidia (PGT-A) View the Video
Journal Global Club From TSRM 2024: Preimplantation genetic testing for aneuploidy in unexplained recurrent pregnancy loss: A systematic review and meta-analysis
Explore the effectiveness of PGT-A in managing unexplained recurrent pregnancy loss, featuring systematic review findings, insights on miscarriage risks, and live birth rates. View the Video
Genetics: Counseling Fertility Couples About Their Evaluation
Caitlin Hebert discusses fertility counseling, the importance of carrier screening, and overcoming barriers for patients while highlighting the role of genetic counseling. View the ASRMed Talk Video
Use of preimplantation genetic testing for monogenic adult-onset conditions: an Ethics Committee opinion (2024)
Preimplantation genetic testing for adult-onset monogenic diseases is ethically allowed when fully penetrant or conferring disease predisposition. View the Committee Opinion
Codes for Embryo Biopsy
When doing a preimplantation genetic test (PGT) biopsy, can you bill for each day a biopsy is performed or can you only bill once for the cycle? View the Answer
The use of preimplantation genetic testing for aneuploidy: a committee opinion (2024)
PGT-A use in the U.S. is rising, but its value as a routine IVF screening test is unclear, with mixed results from various studies. View the Committee Opinion
Journal Club Global: Recent clinical trials in Fertility and Sterility from the Asia Pacific region
Join ASPIRE 2024 for a Journal Club Global on PGT-A and IVF. Learn from top experts discussing recent clinical trial data and pregnancy outcomes View the Video
Coding for an endometrial biopsy/Mock cycle
We had patients request us to bill their insurance for the two monitoring visits and the Endo BX and change the diagnosis code to something that is payable. View the Answer
Journal Club Global: Cost effectiveness analyses of PGT-A
Infertility treatments can be financially burdensome, often without insurance coverage, making understanding the cost effectiveness of PGT-A crucial. View the Video
Coding PGT requisitions to the PGT lab
Do you have any recommended codes to use for PGT requisitions to the PGT lab? View the Answer
Genetics: Is Expanded Carrier Screening the Standard of Care?
Hannah Green, a genetic counselor at NYU, discusses the benefits and limitations of expanded carrier screening, highlighting its impact on clinical practice and patient care. View the ASRMed Talk Video
Genetics - Extra Testing, Passthrough or Money Maker?
Danielle Soltesz of RMA New York discusses the complex economics and ethical considerations of genetic testing in reproductive medicine, exploring costs, patient care, and sustainability. View the ASRMed Talk Video
Clinical management of mosaic results from preimplantation genetic testing for aneuploidy of blastocysts: a committee opinion (2023)
This document incorporates studies about mosaic embryo transfer and provides evidence-based considerations for embryos with mosaic results on PGT-A. View the Committee Opinion
Journal Club Global - Revisiting the STAR trial: The Fellows debate PGT-A
We are excited to host a debate covering the pros and cons of PGT-A and how new technologies should be validated before clinical implementation. View the Video
Indications and management of preimplantation genetic testing for monogenic conditions: a committee opinion (2023)
ASRM has updated its opinion on PGT for monogenic conditions, providing guidance on clinical and technical complexities. View the Committee Opinion
Results Review
What CPT code is most appropriate to submit for Physician Time to review CCS/PGS/PGD results? View the Answer
Sperm DNA Fragmentation
Is there a CPT code for HALO DNA Fragmentation for sperm? View the Answer
ICSI and Embryo Biopsy
How to bill for ICSI or embryo biopsies that occur in different days? View the Answer
Embryo Biopsy
Have any new codes been introduced for the lab portion of PGT? View the Answer
Embryo Biopsy Embryologist Travel Costs
Can we bill insurance for the biopsy procedure? Can we bill for travel expenses? View the Answer
Embryo Biopsy PGS Testing
What codes are appropriate for PGS testing? View the Answer
Genetic Counseling
Does ASRM have any guidance for how to bill for genetic counseling services provided by a genetic counselor?View the Answer
Assisted Zona Hatching
Can assisted hatching and embryo biopsy for PGT-A; PGT-M or PGT-SR be billed during the same cycle? View the Answer
Journal Club Global - PGT-A - Can non-invasive approaches based on spent medium analysis
PGT-A by trophectoderm biopsy aims to select available euploid embryos for transfer. View the Video
ASRM müllerian anomalies classification 2021
The Task Force set goals for a new classification and chose to base it on the iconic AFS classification from 1988 because of its simplicity and recognizability. View the Committee Opinion
Journal Club Global - Accuracy of Preimplantation Genetic Testing for Aneuploidies
One of the highest aspirations in reproductive medicine is to develop a technology allowing for ID of embryos that have true reproductive potential.
View the Video
Disclosure of sex when incidentally revealed as part of preimplantation genetic testing (PGT): an Ethics Committee opinion (2018)
Clinics may develop a policy to disallow selecting which embryos to transfer based on sex and choose to use only embryo quality as selection criteria. View the Committee Opinion
Best practices of ASRM and ESHRE: a journey through reproductive medicine (2012)
ASRM and ESHRE are the two largest societies in the world whose members comprise the major experts and professionals working in reproductive medicine. View the Committee Joint Guideline
