BRCA mutations and embryo aneuploidy: is there a link?

The prevalence of BReast Cancer Gene (BRCA1 or BRCA2) mutation ranges from roughly 1 in 300 to 1 in 800 individuals, and although the lifetime risk of breast cancer for the “typical American”

The measure of a place: neighborhood disadvantage and menstrual disturbances

There are ample data to support the association between environmental exposures and health outcomes across the gynecologic, reproductive, and obstetric literature (1, 2). Much less is known about

An area under the receiver operating characteristic curve: good enough for what and when?

A new biomarker predicts live birth after application of a test for embryo selection with an area under the receiver operating characteristic curve (AUC) of 0.72. The investigators conclude that

Fertility preservation in patients with genetic conditions predisposing to primary ovarian insufficiency

Advances in genomic medicine have substantially expanded the spectrum of genetic conditions associated with primary ovarian insufficiency (POI), enabling the identification of women and girls at

Associations of Maternal Polyendocrine Metabolic Ovarian Syndrome with Offspring Ovarian Activity in Minipuberty

To study whether maternal PMOS is associated with altered ovarian activity in infant daughters during minipuberty.

Preimplantation genetic testing laboratory classification strategies are associated with diagnostic yield and downstream clinical performance

To evaluate whether PGT-A laboratory was associated with diagnostic yield and live birth per single euploid embryo transfer.

When Absence of Evidence Is Not Evidence of Absence: Limitations of Claims-Based Assessments of Fertility Care

Fertility evaluation of infertile women: a committee opinion

Diagnostic evaluation for infertility in women should be conducted in a systematic, expeditious, and cost-effective manner to identify all the relevant factors with an initial emphasis on the

Pathogenic variants in GALNT3, GALNT8, and GALNTL5 are associated with distinct sperm defects in human asthenoteratozoospermia

To investigate the contribution of variants in the GALNT gene family to male infertility and to evaluate the outcomes of intracytoplasmic sperm injection (ICSI) in infertile patients carrying

Raising the roof on the endometrial threshold: does a thicker lining build a healthier baby, or just a heavier one?

For much of the modern assisted reproductive technology (ART) era, efforts at clinical optimization have suffered from a strong embryo-centric bias. We grade, image, and biopsy the “seed” with