The ASRM Service Milestone Award recognizes 10, 15, and 20-year milestones for service.
What's New from the Fertility and Sterility Family of Journals
September: What's New from the Fertility and Sterility Family of Journals
Date: September 23, 2024
Author: ASRM
Here’s a peek at this month’s issues from our family of journals! As an ASRM Member, you can access all of our journals.
From Fertility and Sterility
In vitro fertilization practice in patients with absolute uterine factor undergoing uterus transplant in the United StatesThirty-one uterus transplant recipients were included in this study. Before transplant, recipients completed a mean of two oocyte retrievals (range 1–4), banking a mean of eight untested embryos (range 3–24) or six euploid embryos (range 2–10). Posttransplant retrieval cycles were required in 19% (n = 6/31) of recipients, for a total of 16 cycles (range 2–4 cycles per recipient). All posttransplant retrievals were performed vaginally without complications. The overall LBR after the first ET was 57% (n = 13/23) and rose to 74% (n = 17/23) after a second ET. There was no difference in rate of preeclampsia, live birth, neonatal birth, or placental weights among programmed vs. natural cycle frozen ETs. There were no differences in the LBR between living or deceased donor uteri (37% vs. 32%). Future reporting of IVF treatment experiences will be essential to optimizing reproductive outcomes after a uterus transplant.
From F&S Reports
Progesterone in frozen embryo transfer cycles: assays, circulating concentrations, metabolites, and molecular actionProgrammed or medicated frozen embryo transfer cycles rely on exogenous progesterone (P) administration to prepare the endometrium for implantation and maintain pregnancy. Presently, the optimal route and dose of P replacement for frozen embryo transfer are not known. This mini-review discusses how different P assay methodologies affect the determination of P thresholds for implantation and pregnancy maintenance. In addition, it discusses the importance of free P and its regulation in the endometrium and show the complexity of molecular signaling that is required for P-dependent endometrial receptivity. Future studies should focus on defining accurate circulating and endometrial P concentrations, both for total and free P, and how these concentrations correlate with endometrial receptivity and clinical outcomes.
From F&S Science
A seed or soil problem in early endometriosis: stromal cell origin drives cellular invasion and coupling over mesothelial cell originThis paper studied the role of the mesothelial cells in early endometriosis lesion formation by assessing in vitro cell-to-cell communication and invasion of endometrial cells across a mesothelial cell monolayer, with both cell types derived from both patients with endometriosis and control patients. Although both endometrial and mesothelial cells need to function for establishment of endometriosis lesions, the endometrium seems to be the key player, serving as an ideal target for diagnostic strategies and therapeutic intervention. While this notion is consistent with previous studies, this is the first to directly test both primary mesothelial and endometrial cells from patients with endometriosis and control patients to compare propensities for mesothelial invasion.
From F&S Reviews
Polycystic ovary syndrome and miscarriage: a narrative reviewPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. Although women with PCOS are often identified when presenting for oligomenorrhea or infertility care, PCOS is also linked to several metabolic morbidities, which may predispose to poor reproductive outcomes. Research has also suggested a possible independent association between PCOS and miscarriage, although available data are conflicting. This review focuses on the current literature regarding the risk of miscarriage and recurrent pregnancy loss in women with PCOS. First, it gives an overview of the prevalence of miscarriage and recurrent pregnancy loss in this population and identify study limitations that contribute to the conflicting data regarding the potential association. Subsequently, it reviews the current literature on obesity, insulin resistance and hyperinsulinemia, thrombophilia, hyperandrogenism, oocyte, and embryo quality and viability, endometrial receptivity, oxidative stress and chronic inflammation, in addition to the efficacy of potential risk-mitigating interventions for miscarriage in women with PCOS.
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September: What's New from the Fertility and Sterility Family of Journals
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Welcome New ASRM Members!
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July: What's New from the Fertility and Sterility Family of Journals
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What's New from the Fertility and Sterility Family of Journals
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What's New from the Fertility and Sterility Family of Journals
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What's New from the Fertility and Sterility Family of Journals
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Fertility and Sterility
Access to all F&S journals are included with ASRM membership
Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.
View the Fertility and Sterility sister Journals at:
FertStertReports.org
FertStertReviews.org
FertStertScience.org
The News from ASRM
Latest News
An indispensable news digest for reproductive scientists, clinicians and allied health professionals. The Latest News posts are available to ASRM members in good standing only.
ASRM Press Releases/Bulletins
ASRM Press Releases and Bulletins are published by ASRM's Office of Public Affairs to inform the press and Society members of important recent developments.
Legally Speaking Column
Legally Speaking is a column highlighting recent court decisions affecting the assisted reproductive technologies and the families they create, written by Susan L. Crockin, J.D. and guest authors who offer unique perspectives and expertise on significant legal topics.